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Tuesday, July 21 • 4:30pm - 5:00pm
W05 S06: Modulation of corticothalamic rhythmogenic circuits in depressed patients by rTMS neurostimulation therapy

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This session is part of W05: Spatiotemporal Dynamics in Neuroimaging: Models and Analysis

Repetitive transcranial magnetic stimulation (rTMS) is routinely used in the clinic as an alternative therapy for patients with treatment-resistant depression. Very little is known, however, about the physiological basis of rTMS effects, and how these relate to alleviation of symptoms. In this talk I summarize our recent work examining the influence of rTMS on spatiotemporal brain dynamics using an established model of EEG rhythm generation in the corticothalamic system. Comparison of parameter estimates from models fitted to patient EEG data before and after rTMS therapy yields putative physiological changes induced by the intervention. In particular, we find statistically significant reductions in excitatory corticothalamic gains in models fitted to post- as compared to pre- stimulation therapy resting EEG data. Interestingly, these modulations extend well beyond the primary stimulation site in the frontal lobe, indicating a key role for large-scale networks in the transmission of modulatory rTMS effects. Projection to the model’s reduced 3-dimensional parameter space allows interpretation of these rTMS-induced changes in terms of the principal instabilities, and associated spectral signatures, of corticothalamic activity.

Send your questions to our Q & A Space: https://neurostars.org/t/workshop-spatiotemporal-dynamics-in-neuroimaging-models-and-analysis-q-a/7608?u=psanzleon


John Griffiths

Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health

Tuesday July 21, 2020 4:30pm - 5:00pm CEST
Crowdcast (W05)