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Wednesday, July 22 • 4:30pm - 5:00pm
W2 S21: Exploring the origin of spatiotemporal patterns of glial calcium by a compartmental model of astrocytic physiology

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The growing recognition of spatial compartmentalization of intracellular calcium signals in glial cells such as astrocytes, is regarded as a potential biophysical correlate for the many functions that those cells could fulfill. Nonetheless, we currently miss any understanding of the biophysical mechanisms underpinning such compartmentalization. We present work in progress on an in silico model of astrocytic calcium signaling that combines diffusion of calcium with reaction-diffusion of inositol 1,4,5-trisphosphate. Consideration of different elemental branching configurations allows identification by analytical and numerical approaches of a variety of constraints of cell’s anatomy for the emergence of spatially-confined calcium dynamics.

avatar for Evan Cresswell-Clay

Evan Cresswell-Clay

Postdoc Researcher, National Institute of Health
I am a Postdoctoral Fellow in the Labratory of Biological Modeling at the NIDDK. I am currently working on data-driven modeling of tertiary protein structure. I utilize methods from information theory to infer spatial contacts from multiple sequence alignments. My PhD work was in... Read More →

Wednesday July 22, 2020 4:30pm - 5:00pm CEST
Crowdcast (W02)