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Wednesday, July 22 • 4:00pm - 4:30pm
W2 S20: Calcium release through IP3 receptors equips cells with a fast way to reprogram intracellular calcium signals

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Many intracellular calcium signals involve calcium release into the cytosol through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs)/calcium channels. IP3Rs need to bind calcium and IP3 to become open. Thus, IP3R-mediated calcium signals can spread through calcium-induced calcium release (CICR) in which the calcium released through an open channel induces the opening of neighboring ones. IP3Rs, however, are also inhibited by high calcium concentrations. This implies that IP3Rs act as "coincidence" detectors where the timing between the relative increase of IP3 and calcium in their vicinity leads to signals that can propagate or remain spatially localized. The nature of the resulting signal has implications for the subsequent end response. Thus, IP3R-mediated calcium release equips cells with a fast way to reprogram their responses. In this talk I will show modeling results that highlight the role of this mechanism in synaptic plasticity. In particular, I will show how the co-existence of different types of changes in homo- and hetero-synapses induced by different protocols can be explained in terms of the differential way in which the IP3 and calcium concentrations increase and how this impacts on the resulting intracellular calcium signal being propagating or not.

avatar for Silvina Ponce Dawson

Silvina Ponce Dawson

Professor, Silvina Ponce Dawson
I am a physicist doing research in biological physics. I am particularly interested in cell signaling and information processing in biological systems.

Wednesday July 22, 2020 4:00pm - 4:30pm CEST
Crowdcast (W02)