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Wednesday, July 22 • 10:00am - 10:30am
W2 S11: Modeling calcium signaling in live animals

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The vast majority of previous experimental and theoretical work on calcium signalling has been in cell lines, cultured cells, or, more recently, in whole organs. The underlying assumption of these studies is that the mechanisms that control calcium signalling in a live animal are essentially similar, and one can extrapolate from one to the other. Although this assumption is, to a large extent, valid and useful, recent measurements of cytosolic calcium oscillations in salivary acinar cells from a live mouse have necessitated a major rethink of the mechanisms underlying whole-cell calcium responses and water transport in salivary cells. We shall present these new experimental data, and show how previous models have needed to be significantly modified in order to understand and explain these new results.


James Sneyd

Professor, University of Auckland
Calcium dynamics, mathematical modelling of physiological processes, cell signalling, dynamical systems, oscillations and travelling waves in physiology and neuroscience.

Wednesday July 22, 2020 10:00am - 10:30am CEST
Crowdcast (W02)