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Tuesday, July 21 • 4:30pm - 5:00pm
W2 S10: Calcium as trigger of synaptic plasticity

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Multiple stimulation protocols have been found to be effective in changing synaptic efficacy by inducing long-term potentiation or depression. In many of those protocols, increases in postsynaptic calcium concentration have been shown to play a crucial role. Here, we discuss a calcium-based model of a synapse in which potentiation and depression are activated whenever calcium crosses distinct thresholds. We show that this model gives rise to a large diversity of spike-timing-dependent plasticity curves, most of which have been observed experimentally in different systems. Moreover, we use the model to investigate synaptic changes elicited by in vivo-like firing, where cells fire irregularly, and the timing between pre- and postsynaptic spikes varies. We show that the influence of spike-timing on plasticity is weaker than expected from regular stimulation protocols. The model provides a mechanistic understanding of how various stimulation protocols provoke specific synaptic changes through the dynamics of calcium concentration and thresholds implementing in simplified fashion protein signaling cascades, leading to long-term potentiation and long-term depression. 

avatar for Michael Graupner

Michael Graupner

Research Scientist, CNRS, Université de Paris

Tuesday July 21, 2020 4:30pm - 5:00pm CEST
Crowdcast (W02)