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Tuesday, July 21 • 9:30am - 10:00am
W2 S01: Elucidating the role of cell architecture and its remodeling in maintaining a healthy heartbeat using high-resolution 3D computational models.

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When an aspiring athlete builds cardiac endurance when a mom-to-be is pregnant and as we all grow and age from tiny embryos into adults, the heart has to generate enough force to pump the blood that the body needs to supply oxygen and nutrients to sustain life. The heart’s ability to pump blood to the rest of the body is determined by the coordinated contraction of millions of its constituent cardiac cells. Soon after completion of embryonic development and formation of the heart, cardiac cells lose their ability to divide and multiply. Therefore, the only way that the heart can increase its force of contraction and capacity to meet long-term increases in demand for blood supply through most of life is by increasing the size and re-arranging the internal components of each cardiac cell to accommodate more force-generating proteins within them. These architectural changes at the cellular level are referred to as cell remodeling and little is known about the biophysical mechanisms that drive this important process of life and how changes to cell architecture impact on cardiac cell signaling and the heartbeat. In this talk, I will present our recent findings on the role that spatial organization of cardiac cell signaling proteins and organelles has on in maintaining a healthy heartbeat. I will demonstrate how we can gain quantitative insights on the contribution of the sub-cellular organization to cell function using 3D computational models of the cell’s subcellular architecture and the signaling processes that are derived from microscopy data. I will also briefly outline our vision for making spatially detailed models useful for drug-discovery applications.

Speakers

Tuesday July 21, 2020 9:30am - 10:00am CEST
Crowdcast (W02)