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Monday, July 20 • 8:00pm - 9:00pm
P199: Stimulation-Induced Decoupling by Spike-Timing-Dependent Plasticity in Neuronal Networks with Propagation Delays

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Note: Poster #198 and poster #P199 will be jointly presented here.

Google Meet link: https://meet.google.com/exp-kbbg-vjp

Note: If you missed the session or would like to learn more about our work, email me at mojtabamadadi7@gmail.com so we can arrange a meeting via Google Meet or Skype and talk more.

Authors: Mojtaba Madadi Asl
, Alireza Valizadeh, Peter A. Tass

Abstract: Several neurological disorders such as Parkinson's disease and epilepsy are characterized by pathological neuronal synchronization in cortical or sub-cortical areas. Therapeutic brain stimulation techniques aimed at shifting the pathological dynamics of the diseased brain towards healthy attractor states, are employed to restore physiological patterns of synaptic connectivity by decoupling strongly connected neurons. Dynamics of cortical neuronal populations crucially depends on the synaptic connectivity of the cortex which continually change by spike-timing-dependent plasticity (STDP). It has recently shown that the effect of the STDP on the structure and the dynamics of the neuronal networks is profoundly dependent on the delay in transmission of the signals between the neurons [2]. In particular, propagation delays lead to multi-stability of the network structure such that strong bidirectional loops, loosely connected pairs of neurons, or asymmetric unidirectional connections can emerge between different pairs of neurons under the influence of STDP [2]. In the present study, by theoretical analysis of a reciprocally coupled two- neuron motif we show that the decoupling of the neurons and neuronal populations by stimulation depends on the imbalance of STDP potentiation/depression rates and time constants and the transmission delays. Then the theoretical predictions were numerically tested in a two-layer model of oscillatory networks composed of excitatory and inhibitory neurons where the individual neurons fire irregularly.

References: For more information on the background, take a look at our related open access publications:

1. Dendritic and axonal propagation delays determine emergent structures of neuronal networks with plastic synapses: https://www.nature.com/articles/srep39682

2. Delay-induced multistability and loop formation in neuronal networks with spike-timing-dependent plasticity: https://www.nature.com/articles/s41598-018-30565-9

avatar for Mojtaba Madadi Asl

Mojtaba Madadi Asl

Researcher, Department of Physics, Institute for Advanced Studies in Basic Sciences (IASBS)
Mojtaba Madadi Asl does research in theoretical neuroscience: Delay-induced dynamics, dynamical systems, synaptic plasticity and spike-timing-dependent plasticity (STDP). They study how patterns of neuronal activity and synaptic connectivity in diseased neuronal networks can be reshaped... Read More →

Monday July 20, 2020 8:00pm - 9:00pm CEST
Slot 18