Google Meet https://meet.google.com/vjz-bbyo-woo
Alberto Perez Cervera,
Jaroslav HlinkaAlthough epilepsy is the most chronic neurological disorder, the mechanisms underlying the initiation of epileptic seizure remain unknown. Epileptic seizures are generated by intense activity emerging from a highly synchronized neuronal population. These phenomena are usually preceded and followed by intervals of reduced activity, known as interictal periods. Importantly, the transient neuronal activity during these interictal periods -known as interictal epileptiform discharges (IEDs)- is considered a key mechanism governing the transition to seizure. However, whether IEDs prevent or facilitate that transition is still a matter of debate. In this work, based on previous findings in [1], we show how these dual effects for IEDs can be interpreted in terms of the phasic response of a slow- fast system. Indeed, since the phase response of a given system follows from its isochrons distribution, we perform a theoretical and computational study of the isochrons and phase response curves of different planar slow-fast epileptic models. Our results unfold the strong influence of the slow vector field in the phasic response of the system to IEDs and suggest theoretical stimulation strategies whose effects range from the short delay to the full suppression of seizures.
References
1\. Chang, Wei-Chih, et al. "Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations." Nature neuroscience 21.12 (2018): 1742-1752.
