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Monday, July 20 • 7:00pm - 8:00pm
P11: Effect of interglomerular inhibitory networks on olfactory bulb odor representations

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Daniel Zavitz
, Isaac Youngstrom, Matt Wachowiak, Alla Borisyuk

Lateral inhibition is a fundamental feature of circuits that process sensory information. In the mouse olfactory system, inhibitory interneurons called short axon cells initially mediate lateral inhibition between glomeruli, the functional units of early olfactory coding and processing. However, their interglomerular connectivity and its impact on odor representations is not well understood. To explore this question, we constructed a computational model of the interglomerular inhibitory network using detailed characterizations of short axon cell morphologies and simplified intraglomerular circuitry. We then examined how this network transformed glomerular patterns of odorant-evoked sensory input (taken from previously- published datasets) at different values of interglomerular inhibition selectivity. We examined three connectivity schemes: selective (each glomerulus connects to few others with heterogeneous strength), nonselective (glomeruli connect to most others with heterogeneous strength) or global (glomeruli connect to all others with equal strength). We found that both selective and nonselective interglomerular networks could mediate heterogeneous patterns of inhibition across glomeruli when driven by realistic sensory input patterns, but that global inhibitory networks were unable to produce input-output transformations that matched experimental data.

We further studied networks whose interglomerular connectivity was tuned by sensory input profile. We found that this network construction improved contrast enhancement as measured by decorrelation of odor representations. These results suggest that, despite their multiglomerular innervation patterns, short axon cells are capable of mediating odorant-specific patterns of inhibition between glomeruli that could, theoretically, be tuned by experience or evolution to optimize discrimination of particular odorants.

avatar for Daniel Zavitz

Daniel Zavitz

Graduate Student, Department of Mathematics, University of Utah

Monday July 20, 2020 7:00pm - 8:00pm CEST
Slot 02