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Sunday, July 19 • 8:00pm - 9:00pm
P213: Local synaptic connections alter spike responses and signal propagation in models of globus pallidus pars externa

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Erick Olivares, Matthew Higgs, Charles WilsonGlobus pallidus pars externa (GPe) has been seen as a relay nucleus in the indirect pathway of the basal ganglia, which simply inverts the inhibitory signal arriving from striatal projection neurons. In this view, the information flowing through GPe runs in parallel paths that do not interact with one another. However, GPe neurons are fast autonomous oscillators that project axon collaterals spanning a wide area, creating an active local inhibitory network. How does the local connectivity affect GPe neurons' steady-state firing and responses to external synaptic input? To answer this question, we constructed network models of GPe, using experimental data to model neurons and synapses and different network architectures to explore the functions of local and longer-range connectivity patterns inside GPe. Our results show that the connectivity affects the spike responses to external input, as well as the dynamics of signal propagation within GPe.

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Erick Olivares

Postdoc, Department of Biology, Universidad de Texas at San Antonio

Sunday July 19, 2020 8:00pm - 9:00pm CEST
Slot 18