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Sunday, July 19 • 7:00pm - 8:00pm
P32: Contribution of the Na/K pump to rhythmic bursting.

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Meeting ID: 980 7721 5494
Password: 916401

Ronald Calabrese
, Ricardo Javier Erazo Toscano, Parker J. Ellingson, Gennady Cymbalyuk

The Na/K pump, often thought of as a background function in neuronal activity, contributes an outward current (IPump) that responds to the internal concentration of Na+ ([Na+]i). In bursting neurons, such as those found in central pattern generators (CPGs) that produce rhythmic movements, one can expect the [Na+]i and thus IPump to vary throughout the burst cycle [1,2,3]. This variation with electrical activity and the independence from membrane potential endow IPump with dynamical properties not available in channel-based currents (e.g. voltage- or transmitter- gated, or leak channels). Moreover, in many neurons the pump’s activity is modulated by a variety of modulators further expanding the potential role of IPump in rhythmic bursting activity [4]. Using a combination of experiment, modeling, and hybrid systems analyses, we have sought to determine how IPump and its modulation influence rhythmic activity in a CPG.


avatar for Ronald Calabrese

Ronald Calabrese

Department of Biology, Emory University

Sunday July 19, 2020 7:00pm - 8:00pm CEST
Slot 16