Loading…
CNS*2020 Online has ended
Welcome to the Sched instance for CNS*2020 Online! Please read the instruction document on detailed information on CNS*2020.
Back To Schedule
Sunday, July 19 • 7:00pm - 8:00pm
P193: Input strength dependence of the beta component of gamma-band auditory steady-state responses in patients with schizophrenia

Log in to save this to your schedule, view media, leave feedback and see who's attending!

Feedback form is now closed.
Link to the Zoom session

If you missed the session and still want to talk or ask questions, email me at cmetzner[at]ni.tu-berlin.de

Christoph Metzner
, Volker Steuber

The mechanisms underlying circuit dysfunctions in schizophrenia (SCZ) remain poorly understood. Auditory steady-state response (ASSRs), especially in the gamma and beta band, have been suggested as a potential biomarker for SCZ. While the reduction of 40Hz power for 40Hz drive has been well established and replicated in SCZ patients, studies are inconclusive when it comes to an increase in 20Hz power during 40Hz drive [1]. There might be several factors explaining the inconsistencies, including differences in the sensitivity of the recording modality (EEG vs MEG), differences in stimuli (click-trains vs amplitude-modulated tones) and also large differences in the amplitude of the stimuli.

Here, we used a computational model of ASSR deficits in SCZ [2,3,4], in which increased IPSC decay times at GABAergic synapses produce ASSR deficits as seen experimentally. We investigated the effect of input strength on gamma and beta band power during gamma ASSR stimulation. We found that the pronounced increase in beta power during gamma stimulation seen experimentally could only be reproduced in the model for a specific range of input strengths. More specifically, if the input was too weak the network failed to produce a strong oscillatory rhythm. When the input was in the specific range, the rhythmic drive at 40Hz produced a strong 40Hz rhythm in the control network, however, in the ‘SCZ-like’ network, the prolonged inhibition led to a so-called ‘beat- skipping’, where the network would only strongly respond to every other input. This mechanism was responsible for the emergence of the pronounced 20Hz beta peak in the power spectrum. However, if the input exceeded a certain strength value, the 20Hz peak in the power spectrum disappeared again. In this case, prolonged inhibition due to the increased IPSC times was insufficient to suppress the now stronger gamma drive from the input, resulting in an absence of the beat-skipping and single peak at 40Hz in the power spectrum.

Here, we employed an established model of gamma and beta band ASSR deficits in SCZ to explore the dependence of a beta component in response to gamma drive on the strength of the input. Our finding that the beta component only existed for a specific range of input strengths might explain the seemingly inconsistent reporting in experimental studies and suggests that future ASSR studies should explicitly explore different amplitudes of their stimuli.

References

1\. Thune H, Recasens M, Uhlhaas PJ. The 40-Hz auditory steady-state response in patients with schizophrenia: a meta-analysis. JAMA Psychiatry 2016, 73(11).

2\. Vierling-Claassen D, Siekmeier P, Stufflebeam S, & Kopell N. Modeling GABA alterations in schizophrenia: a link between impaired inhibition and altered gamma and beta range auditory entrainment. J Neurophysiol 2008, 99(5).

3\. Metzner C. [Re] Modeling GABA alterations in schizophrenia: a link between impaired inhibition and gamma and beta auditory entrainment. ReScience 3(1).

4\. Metzner C, Zurowski B, & Steuber V. The role of parvalbumin-positive interneurons in auditory steady-state response deficits in schizophrenia. Sci Rep (2019), 9(1).

Speakers
avatar for Christoph Metzner

Christoph Metzner

PostDoc, Department of Software Engineering and Theoretical Computer Science, Technische Universität Berlin



Sunday July 19, 2020 7:00pm - 8:00pm CEST
Slot 10