CNS*2020 Online has ended
Welcome to the Sched instance for CNS*2020 Online! Please read the instruction document on detailed information on CNS*2020.
Back To Schedule
Sunday, July 19 • 7:00pm - 8:00pm
P210: Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy

Log in to save this to your schedule, view media, leave feedback and see who's attending!

Feedback form is now closed.
Zoom meeting link

Yujiang Wang


Personalised medicine requires that treatments adapt to not only the patient, but changing factors within each individual. Although epilepsy is a dynamic disorder characterised by pathological fluctuations in brain state, surprisingly little is known about whether and how seizures vary in the same patient. We quantitatively compared within-patient seizure network evolutions using intracranial electroencephalographic (iEEG) recordings of over 500 seizures from 31 patients with focal epilepsy (mean 16.5 seizures/patient). In all patients, we found variability in seizure paths through the space of possible network dynamics. Seizures with similar pathways tended to occur closer together in time (Fig. 1), and a simple model suggested that seizure pathways change on circadian and/or slower timescales in the majority of patients. These temporal relationships occurred independent of whether the patient underwent antiepileptic medication reduction. Our results suggest that various modulatory processes, operating at different timescales, shape within-patient seizure evolutions, leading to variable seizure pathways that may require tailored treatment approaches.


Schroeder GM, Diehl B, Chowdhury FA, Duncan JS, de Tisi J, Trevelyan AJ, Forsyth R, Jackson A, Taylor PN, Wang Y. Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy. Proc Natl Acad Sci U S A. 2020;117(20):11048-11058. doi:10.1073/pnas.1922084117

avatar for Yujiang Wang

Yujiang Wang

Principal Investigator, Newcastle University

Sunday July 19, 2020 7:00pm - 8:00pm CEST
Slot 05