https://zoom.us/j/98077215494?pwd=dTlhbml4TFd2M2hvWGVFSlV2RXJHQT09
Meeting ID: 980 7721 5494
Password: 916401
Ronald Calabrese,
Ricardo Javier Erazo Toscano,
Parker J. Ellingson,
Gennady CymbalyukThe Na/K pump, often thought of as a background function in neuronal activity, contributes an outward current (IPump) that responds to the internal concentration of Na+ ([Na+]i). In bursting neurons, such as those found in central pattern generators (CPGs) that produce rhythmic movements, one can expect the [Na+]i and thus IPump to vary throughout the burst cycle [1,2,3]. This variation with electrical activity and the independence from membrane potential endow IPump with dynamical properties not available in channel-based currents (e.g. voltage- or transmitter- gated, or leak channels). Moreover, in many neurons the pump’s activity is modulated by a variety of modulators further expanding the potential role of IPump in rhythmic bursting activity [4]. Using a combination of experiment, modeling, and hybrid systems analyses, we have sought to determine how IPump and its modulation influence rhythmic activity in a CPG.
Teaser:
https://youtu.be/vtt3qtsu8hQ
